LncRNAs and immunity: watchdogs for host pathogen interactions

Table 1 Functions of immune related lncRNAs

S. No.	lncRNA	Function	Reference
1	Hotair	Promotes cancer metastasis and progression via epigenetic variations in the chromatin state	[31]
2	Lnc-IL7R	Epigenetically regulates inflammation	[15]
3	NRON	Transcription regulator for immune regulation	[33]
4	NeST/Tmevpg1	Epigenetically regulates the adaptive immunity through IFN-gamma	[24, 34, 35]
5	IL1β	Chromatin modulation.	[14]
6	IL1β-RBT46	Regulates the homeostasis of IL-1β in monocytes	[14]
7	IL1b-eRNA	Expression of proinflammatory mediators e.g., CXCL8 and IL-1β	[14]
8	PACER	Involved in multiple processs related to regulation of immunogene expression	[21]
9	LincRNA-COX2	Role in TLR-induced expression of interleukin-6	[7, 22]
10	Lnc-DC	Required for the differentiation of monocytes to dendritic cells	[20]
11	Lethe	Upregulated during inflammation	[19]
12	THRIL	Regulate expression of tumour necrosis factor (TNF) in human monocytes	[10, 23]
13	PAN	epigenetically regulates viral gene expression and promotes the switch from latent to lytic infection	[52, 54]
14	NRAV	Modulation of transcription of multiple interferon-stimulated genes (ISGs) i.e,. MxA and IFITM3	[55]
15	NEAT1	Triggers transcriptional activation of IL-8 in response to viral infection	[10]

ISSN: 1480-9222