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Figure 5 | Biological Procedures Online

Figure 5

From: The functional role of long non-coding RNAs and epigenetics

Figure 5

Long non-coding RNAs in nuclear sub-compartments. Human NEAT1 (Menϵin mouse) localizes to para-speckles and it is required for para-speckle structural integrity. NEAT2 (MALAT1) localizes to splicing speckles but it is not required for their structural integrity. Nascent Menβ and MALAT1 transcripts can each be processed by the unusual mechanism of RNase P cleavage to generate the 5’ end of mascRNA (MALAT1- associated small cytoplasmic RNA) and the 3’ end of the mature Menβ and MALAT1 transcripts, which localize to paraspeckles and splicing speckles, respectively.

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