Table 1 The severity of RA histology in tissue sections of control and CIA mice
Shoulder joint | Elbow joint | Knee joint | Ankle joint | ||||||
|---|---|---|---|---|---|---|---|---|---|
L | R | L | R | L | R | L | R | ||
Control mice | |||||||||
Mouse 1 | inflammation | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
synovial hyperplasia | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
pannus formation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
bone/cartilage loss | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Score | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | |
Mouse 2 | inflammation | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
synovial hyperplasia | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | |
pannus formation | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
bone/cartilage loss | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | |
Score | 4 | 2 | 2 | 3 | 1 | 0 | 1 | 0 | |
Mouse 3 | nd | ||||||||
CIA mice | |||||||||
Mouse 1 | inflammation | 0 | 2 | 3 | 2 | 2 | 3 | 3 | 3 |
synovial hyperplasia | 1 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | |
pannus formation | 0 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | |
bone/cartilage loss | 0 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | |
Score | 1 | 11 | 12 | 8 | 11 | 12 | 12 | 12 | |
Mouse 2 | inflammation | 0 | 3 | 1 | 1 | 3 | 3 | 2 | 3 |
synovial hyperplasia | 0 | 3 | 2 | 2 | 3 | 3 | 2 | 3 | |
Pannus formation | 0 | 3 | 2 | 2 | 3 | 3 | 2 | 3 | |
bone/cartilage loss | 1 | 2 | 1 | 2 | 3 | 3 | 2 | 3 | |
Score | 1 | 11 | 6 | 7 | 12 | 12 | 8 | 12 | |
Mouse 3 | inflammation | 2 | 3 | 1 | 2 | 2 | 2 | 1 | 2 |
synovial hyperplasia | 1 | 3 | 1 | 3 | 3 | 3 | 2 | 3 | |
pannus formation | 2 | 3 | 1 | 3 | 3 | 3 | 1 | 3 | |
bone/cartilage loss | 2 | 3 | 1 | 3 | 3 | 3 | 1 | 3 | |
Score | 7 | 12 | 4 | 11 | 11 | 11 | 5 | 11 | |
Mouse 4 | inflammation | 3 | 3 | 3 | 2 | 3 | 2 | 3 | 3 |
synovial hyperplasia | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
pannus formation | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
bone/cartilage loss | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 3 | |
Score | 12 | 12 | 12 | 10 | 12 | 11 | 12 | 12 | |
Mouse 5 | inflammation | 3 | 3 | 3 | 1 | 3 | 3 | 2 | nd |
synovial hyperplasia | 2 | 3 | 3 | 1 | 3 | 3 | 3 | nd | |
pannus formation | 2 | 3 | 3 | 1 | 3 | 3 | 2 | nd | |
bone/cartilage loss | 1 | 3 | 2 | 1 | 2 | 3 | 2 | nd | |
Score | 8 | 12 | 11 | 4 | 11 | 12 | 9 | nd | |
Mouse 6 | nd | ||||||||