Table 2 Morphometric measurements for which aberrant crypts were evaluated

Classification

CRYPTCOUNT

Total number of crypts per ACF

6.7 ± 5.4

Area

ACF_AREA

Area of each ACF in square microns (μm² × 10⁴)

2.5 ± 1.5

ACF_EPIAREA

ACF epithelial area (μm² × 10⁴) (ACFAREA–CSUMAREA)

2.3 ± 1.3

C_SUMAREA

Sum of crypt area (μm² × 10³)

2.2 ± 2.5

C_AVGAREA

Average crypt area in square microns (μm² × 10²)

3.4 ± 1.7

Diameter

ACF_DIAAVG

ACF average diameter in microns (μm × 10²)

1.7 ± 0.5

C_AVGMAXDIA

Crypt maximum diameter in microns (μm × 10)

3.0 ± 1.0

C_AVGSIZELEN

Crypt average size length in microns (μm × 10)

2.9 ± 1.1

Perimeter

ACF_PERIM

ACF perimeter in microns (μm × 10²)

5.6 ± 1.6

C_AVGPERIM

Average crypt perimeter in microns (μm × 10)

6.8 ± 2.7

Roundness

ACF_ROUND

ACF roundness (1 = round, higher numbers indicate polygonal shape)

1.1 ± 0.1

C_AVGROUND

Average crypt roundness (1 = round, high numbers indicate polygonal shape)

2.2 ± 0.6

C_ROUNDCAT

Crypt roundness category: 0–4

1.7 ± 0.7

Density

ACF_DEN

ACF density

0.5 ± 0.2

ACF_IOD

ACF integrated optical density (area × density) (μm² × 10⁴)

1.2 ± 0.9

HID-AB staining

P_SULFOAREA

Percent sulfomucin area (HID stain only) (%)

55 ± 32

P_SIALOAREA

Percent sialomucin area (AB stain only) (%)

16 ± 20

P_UAREA

Percent unstained area (lacks sulfo- and sialomucin HID-AB stain; high numbers, e.g., ≥85% probably indicate MDF) (%)

30 ± 26

MDF

Mucin-depleted foci (≥85% PUAREA)

–