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Figure 7 | Biological Procedures Online

Figure 7

From: Streptozotocin, Type I Diabetes Severity and Bone

Figure 7

Both low and high STZ dose does not influence kidney function, but high dose is associated with liver inflammation. Control (white bar), 40 mg/kg STZ (low dose, gray bar), and 60 mg/kg STZ mice (high dose, black bar) were examined at 19 dpi for markers of kidney function (25-OH vitamin D, BUN, and creatinine serum levels) and liver toxicity (IL-1β and IL-6 RNA levels). For serum analyses, samples were pooled to meet the quantities necessary for measurement. For 25-hydroxyvitamin D: three samples were analyzed per condition (each sample contained serum pooled from one to four individual mice). BUN and creatinine analyses were done on one (high dose) or two (control and low dose) blood samples, each containing serum pooled from five individual mice. IL-6 and C/EBPβ RNA levels were expressed relative to HPRT. Serum values represent mean ± SD. RNA values represent the average ± SE and are expressed relative to control mice (set to 1). *p < 0.05 compared to control; Δ p < 0.05 compared to 40-mg/kg STZ dose.

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