Figure 6

T1-diabetes decreases serum TRAP5b, while high-dose STZ increases cathepsin K and RANKL/OPG ratio. Control (white bar), 40 mg/kg STZ (low dose, gray bar), and 60 mg/kg STZ mice (high dose, black bar) were examined at 19 dpi for osteoclast markers and activity: serum TRAP5b, TRAP5 RNA, cathepsin K RNA, and RANKL/OPG RNA ratio. RNA levels were expressed relative to HPRT. RNA values represent the average ± SE and are expressed relative to control mice (set to 1). *p < 0.05 compared to control. ^Δ p < 0.05 compared to 40-mg/kg STZ dose.