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Figure 5 | Biological Procedures Online

Figure 5

From: Streptozotocin, Type I Diabetes Severity and Bone

Figure 5

STZ-induced T1-diabetes decreases MAR, serum osteocalcin, and bone osteocalcin mRNA while increasing aP2 expression. Control (white bar), 40 mg/kg STZ (low dose, gray bar), and 60 mg/kg STZ mice (high dose, black bar) were examined at 19 dpi for osteoblast parameters: mineral apposition rate (MAR; representative fluorescent images of calcein labeling of bone shown at top of figure), serum osteocalcin (OC), and tibial osteocalcin mRNA levels [expressed relative to hypoxanthine–guanine phosphoribosyl transferase (HPRT), a housekeeping gene). Expression of a mature adipocyte marker, aP2, was also examined. For all RNA analyses, expression was expressed relative to control levels which were set to 1. Values represent the average ± SE. n > 3 per condition, except for high STZ dose MAR (n = 1). *p < 0.05 compared to control; Δ p < 0.05 compared to 40-mg/kg STZ dose.

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