Figure 1

Mice exhibit decreased food intake following the first STZ injection and lose weight despite becoming hyperphagic at later time points. Top panel, Twenty-four-hour food intake (monitored throughout the experiment) is shown at 1, 11, and 18 days post-injection (dpi) for control (white bar), 40 mg/kg STZ (low dose, gray bar), or 60 mg/kg STZ mice (high dose, black bar). Only intake at 1 dpi was significantly decreased. Bottom panel, Mouse body mass was examined throughout the experiment for control (white circles), 40 mg/kg STZ (black square), or 60 mg/kg STZ mice (black triangle). All values represent averages ± SE. n > 3 per condition; *p < 0.05 compared to control.