Fig. 6

Correlation between MBD3 and ACTG1 and the expression of ACTG1 in GC tissues and cells. A Volcano map analysis showed differentially expressed genes in response to sh-EGFP and sh-MBD3 treatment measured by RNA-seq. Green: low expression levels. Red: high expression levels. B The relationship between MBD3 and ACTG1 based on the TCGA dataset. C ACTG1 expression in different cancer types based on the TCGA database. D ACTG1 expression in TCGA-paired cancer and normal tissues. E The expression of ACTG1 was higher in GC than in normal gastric tissues from GTEx database (normal 174 patients) and TCGA database (normal 36 patients, tumor 414 patients). F ACTG1 expression in TCGA-paired GC and normal tissues (normal 27 patients, tumor 27 patients). G Western blotting was used to detect the relative expression levels of ACTG1 in different gastric cell lines (GES-1, SGC-7901, HGC-27 and MGC-803). (*P < 0.05, **P < 0.01, ***P < 0.001)