Table 2 Anti-migration effects of 169 compounds on CYP11A1-overexpressing Caki-1 cells
From: Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Compound name (1st screening) | Tested concentration (µM) | %of free cell area at 0 h | %of free cell area at 24 h | p-value | Compound name (2nd screening) | Tested concentration (µM) | IC50 (µM) | ||
|---|---|---|---|---|---|---|---|---|---|
Caki-1 cell line | ─ | 100 | 12.5 | **** | ─ | ─ | |||
CYP11A1 overexpressed Caki-1 cell line | ─ | 100 | 60.6 | **** | ─ | ||||
CYP11A1 + | AMG | 10 | 100 | 30.2 | **** | 1,5,10,25,50,100 | 25.5 ± 1.4 | ||
CYP11A1 + | Mito | 10 | 100 | 75.4 | **** | 1,5,10,25,50,100 | 18.43 ± 1.2 | ||
1 | CYP11A1 + | NPS-D1-000030-B12 | 10 | 100 | 97.7 | **** | CPK-M1-014010-G04 | 1,5,10,25,50,100 | 112.3 ± 1.6 |
2 | CYP11A1 + | NPS-D1-000042-D04 | 10 | 100 | 97.6 | *** | CPK-M1-014010-H09 | 1,5,10,25,50,100 | 53.0 ± 1.7 |
3 | CYP11A1 + | NPS-D1-000030-A11 | 10 | 100 | 96.5 | **** | CPK-M1-014009-E10 | 1,5,10,25,50,100 | 183.8 ± 0.8 |
4 | CYP11A1 + | NPS-D1-000036-C07 | 10 | 100 | 95.8 | **** | CPK-M1-014010-C04 | 1,5,10,25,50,100 | 107.5 ± 2.0 |
5 | CYP11A1 + | NPS-D1-000029-F08 | 10 | 100 | 95.0 | * | CPK-M1-014009-C12 | 1,5,10,25,50,100 | 141.4 ± 1.5 |
6 | CYP11A1 + | NPS-D1-000042-D10 | 10 | 100 | 94.7 | **** | CPK-M1-014009-H09 | 1,5,10,25,50,100 | 109.4 ± 1.8 |
7 | CYP11A1 + | NPS-D1-000028-A06 | 10 | 100 | 94.7 | * | CPK-M1-014009-H10 | 1,5,10,25,50,100 | 68.7 ± 1.9 |
8 | CYP11A1 + | NPS-D1-000029-F05 | 10 | 100 | 94.6 | **** | CPK-M1-014010-H03 | 1,5,10,25,50,100 | 62.0 ± 2.6 |
9 | CYP11A1 + | NPS-D1-000029-C05 | 10 | 100 | 93.7 | **** | CPK-M1-014009-C07 | 1,5,10,25,50,100 | 82.1 ± 2.1 |
10 | CYP11A1 + | NPS-D1-000028-A03 | 10 | 100 | 93.7 | * | CPK-M1-014009-A06 | 1,5,10,25,50,100 | 111.6 ± 1.8 |
11 | CYP11A1 + | NPS-D1-000032-D08 | 10 | 100 | 93.4 | ** | CPK-M1-014009-C10 | 1,5,10,25,50,100 | 39.0 ± 3.4 |
12 | CYP11A1 + | NPS-D1-000030-D10 | 10 | 100 | 93.1 | * | CPK-M1-014009-B07 | 1,5,10,25,50,100 | 22.7 ± 2.6 |
13 | CYP11A1 + | NPS-D1-000031-G04 | 10 | 100 | 93.1 | ** | CPK-M1-014009-C09 | 1,5,10,25,50,100 | 126.3 ± 1.4 |
14 | CYP11A1 + | NPS-D1-000029-D06 | 10 | 100 | 92.7 | ** | CPK-M1-014009-H03 | 1,5,10,25,50,100 | 50.5 ± 3.3 |
15 | CYP11A1 + | NPS-D1-000028-F12 | 10 | 100 | 92.1 | ** | CPK-M1-014009-A10 | 1,5,10,25,50,100 | 208.7 ± 1.0 |
16 | CYP11A1 + | NPS-D1-000030-D11 | 10 | 100 | 91.7 | **** | CPK-M1-014010-E07 | 1,5,10,25,50,100 | 132.6 ± 1.0 |
17 | CYP11A1 + | NPS-D1-000031-G07 | 10 | 100 | 91.5 | **** | CPK-M1-014009-D09 | 1,5,10,25,50,100 | 130.3 ± 1.3 |
18 | CYP11A1 + | NPS-D1-000043-C03 | 10 | 100 | 91.3 | **** | ─ | ─ | ─ |
19 | CYP11A1 + | NPS-D1-000029-E08 | 10 | 100 | 90.3 | ** | CPK-M1-014010-A03 | 1,5,10,25,50,100 | 95.1 ± 1.3 |
20 | CYP11A1 + | NPS-D1-000035-E10 | 10 | 100 | 90.3 | * | CPK-M1-014009-D08 | 1,5,10,25,50,100 | 90.7 ± 2.0 |
21 | CYP11A1 + | NPS-D1-000043-B11 | 10 | 100 | 90.1 | ** | ─ | ─ | ─ |
22 | CYP11A1 + | NPS-D1-000040-F11 | 10 | 100 | 89.9 | ** | CPK-M1-014009-C03 | 1,5,10,25,50,100 | 31.7 ± 3.8 |
23 | CYP11A1 + | NPS-D1-000029-B07 | 10 | 100 | 89.7 | * | CPK-M1-014010-E06 | 1,5,10,25,50,100 | 95.4 ± 1.5 |
24 | CYP11A1 + | NPS-D1-000030-A05 | 10 | 100 | 89.3 | * | CPK-M1-014010-G07 | 1,5,10,25,50,100 | 166.9 ± 1.0 |
25 | CYP11A1 + | NPS-D1-000039-G07 | 10 | 100 | 89.0 | * | CPK-M1-014009-B09 | 1,5,10,25,50,100 | 43.7 ± 3.0 |
26 | CYP11A1 + | NPS-D1-000027-D11 | 10 | 100 | 89.0 | * | CPK-M1-014010-A10 | 1,5,10,25,50,100 | 195.4 ± 1.0 |
27 | CYP11A1 + | NPS-D1-000030-E06 | 10 | 100 | 88.9 | * | CPK-M1-014009-F06 | 1,5,10,25,50,100 | 104.5 ± 2.0 |
28 | CYP11A1 + | NPS-D1-000029-D07 | 10 | 100 | 88.9 | * | CPK-M1-014009-F03 | 1,5,10,25,50,100 | 32.1 ± 1.9 |
29 | CYP11A1 + | NPS-D1-000037-H03 | 10 | 100 | 88.8 | **** | CPK-M1-014009-C05 | 1,5,10,25,50,100 | 124.4 ± 1.3 |
30 | CYP11A1 + | NPS-D1-000027-E12 | 10 | 100 | 88.5 | * | CPK-M1-014009-C04 | 1,5,10,25,50,100 | 37.6 ± 4.3 |
31 | CYP11A1 + | NPS-D1-000029-A09 | 10 | 100 | 88.4 | **** | CPK-M1-014010-G03 | 1,5,10,25,50,100 | 34.8 ± 3.0 |
32 | CYP11A1 + | NPS-D1-000030-E08 | 10 | 100 | 88.2 | * | CPK-M1-014010-C10 | 1,5,10,25,50,100 | 282.4 ± 1.4 |
33 | CYP11A1 + | NPS-D1-000027-H12 | 10 | 100 | 87.9 | * | CPK-M1-014010-H07 | 1,5,10,25,50,100 | 82.0 ± 2.4 |
34 | CYP11A1 + | NPS-D1-000028-G10 | 10 | 100 | 87.7 | * | CPK-M1-014009-F12 | 1,5,10,25,50,100 | 90.0 ± 1.6 |
35 | CYP11A1 + | NPS-D1-000036-B11 | 10 | 100 | 87.3 | * | CPK-M1-014010-F06 | 1,5,10,25,50,100 | 136.0 ± 1.5 |
36 | CYP11A1 + | NPS-D1-000028-G04 | 10 | 100 | 87.0 | * | CPK-M1-014010-H06 | 1,5,10,25,50,100 | 55.9 ± 3.4 |
37 | CYP11A1 + | NPS-D1-000029-H08 | 10 | 100 | 86.9 | **** | CPK-M1-014009-C08 | 1,5,10,25,50,100 | 152.3 ± 1.3 |
38 | CYP11A1 + | NPS-D1-000029-A06 | 10 | 100 | 86.7 | * | CPK-M1-014009-D12 | 1,5,10,25,50,100 | 93.2 ± 2.3 |
39 | CYP11A1 + | NPS-D1-000028-H05 | 10 | 100 | 86.5 | **** | CPK-M1-014009-G10 | 1,5,10,25,50,100 | 93.1 ± 2.6 |
40 | CYP11A1 + | NPS-D1-000028-C03 | 10 | 100 | 86.3 | * | CPK-M1-014010-F10 | 1,5,10,25,50,100 | 443.7 ± 4.2 |
41 | CYP11A1 + | NPS-D1-000029-D05 | 10 | 100 | 86.3 | **** | CPK-M1-014010-A11 | 1,5,10,25,50,100 | 169.8 ± 1.0 |
42 | CYP11A1 + | NPS-D1-000036-G08 | 10 | 100 | 86.0 | **** | CPK-M1-014010-G11 | 1,5,10,25,50,100 | 41.2 ± 3.0 |
43 | CYP11A1 + | NPS-D1-000041-A10 | 10 | 100 | 85.9 | * | CPK-M1-014009-D05 | 1,5,10,25,50,100 | 50.5 ± 2.0 |
44 | CYP11A1 + | NPS-D1-000041-A11 | 10 | 100 | 85.8 | * | CPK-M1-014009-H06 | 1,5,10,25,50,100 | 52.8 ± 3.8 |
45 | CYP11A1 + | NPS-D1-000029-E09 | 10 | 100 | 85.8 | * | CPK-M1-014010-A09 | 1,5,10,25,50,100 | 73.7 ± 3.0 |
46 | CYP11A1 + | NPS-D1-000040-C10 | 10 | 100 | 85.7 | * | CPK-M1-014010-E08 | 1,5,10,25,50,100 | 64.8 ± 1.8 |
47 | CYP11A1 + | NPS-D1-000028-B08 | 10 | 100 | 85.6 | * | CPK-M1-014010-A07 | 1,5,10,25,50,100 | 14.5 ± 3.9 |
48 | CYP11A1 + | NPS-D1-000028-E12 | 10 | 100 | 85.6 | ** | CPK-M1-014009-B06 | 1,5,10,25,50,100 | 59.5 ± 4.3 |
49 | CYP11A1 + | NPS-D1-000028-G11 | 10 | 100 | 85.1 | * | CPK-M1-014010-B11 | 1,5,10,25,50,100 | 14.6 ± 3.8 |
50 | CYP11A1 + | NPS-D1-000042-F04 | 10 | 100 | 85.0 | **** | CPK-M1-014010-F08 | 1,5,10,25,50,100 | 57.2 ± 3.0 |
51 | CYP11A1 + | NPS-D1-000028-C07 | 10 | 100 | 84.9 | **** | CPK-M1-014009-G09 | 1,5,10,25,50,100 | 124.0 ± 1.8 |
52 | CYP11A1 + | NPS-D1-000029-C07 | 10 | 100 | 84.8 | * | CPK-M1-014009-E12 | 1,5,10,25,50,100 | 89.1 ± 1.2 |
53 | CYP11A1 + | NPS-D1-000042-D09 | 10 | 100 | 84.8 | * | CPK-M1-014010-E09 | 1,5,10,25,50,100 | 60.1 ± 2.2 |
54 | CYP11A1 + | NPS-D1-000029-G05 | 10 | 100 | 84.7 | * | CPK-M1-014010-D07 | 1,5,10,25,50,100 | 33.7 ± 3.0 |
55 | CYP11A1 + | NPS-D1-000037-E04 | 10 | 100 | 84.5 | * | CPK-M1-014009-D04 | 1,5,10,25,50,100 | 43.8 ± 4.1 |
56 | CYP11A1 + | NPS-D1-000029-G07 | 10 | 100 | 84.4 | **** | CPK-M1-014009-D03 | 1,5,10,25,50,100 | 37.1 ± 3.9 |
57 | CYP11A1 + | NPS-D1-000027-A11 | 10 | 100 | 84.4 | ** | CPK-M1-014010-F11 | 1,5,10,25,50,100 | 41.8 ± 4.2 |
58 | CYP11A1 + | NPS-D1-000028-A04 | 10 | 100 | 84.3 | **** | CPK-M1-014009-G12 | 1,5,10,25,50,100 | 74.2 ± 1.5 |
59 | CYP11A1 + | NPS-D1-000030-F05 | 10 | 100 | 84.1 | **** | CPK-M1-014009-G06 | 1,5,10,25,50,100 | 136.2 ± 1.6 |
60 | CYP11A1 + | NPS-D1-000039-D07 | 10 | 100 | 84.0 | **** | CPK-M1-014010-H04 | 1,5,10,25,50,100 | 109.6 ± 2.0 |
61 | CYP11A1 + | NPS-D1-000033-E07 | 10 | 100 | 84.0 | ** | CPK-M1-014009-C06 | 1,5,10,25,50,100 | 61.3 ± 3.5 |
62 | CYP11A1 + | NPS-D1-000028-D03 | 10 | 100 | 84.0 | * | CPK-M1-014010-E12 | 1,5,10,25,50,100 | 38.9 ± 2.9 |
63 | CYP11A1 + | NPS-D1-000043-A10 | 10 | 100 | 83.9 | **** | CPK-M1-014010-G05 | 1,5,10,25,50,100 | 144.3 ± 1.2 |
64 | CYP11A1 + | NPS-D1-000030-D06 | 10 | 100 | 83.8 | * | CPK-M1-014010-E11 | 1,5,10,25,50,100 | 36.3 ± 2.1 |
65 | CYP11A1 + | NPS-D1-000043-G05 | 10 | 100 | 83.8 | * | ─ | ─ | ─ |
66 | CYP11A1 + | NPS-D1-000035-D08 | 10 | 100 | 83.8 | **** | CPK-M1-014009-E05 | 1,5,10,25,50,100 | 60.0 ± 1.7 |
67 | CYP11A1 + | NPS-D1-000028-G12 | 10 | 100 | 83.5 | * | CPK-M1-014010-C08 | 1,5,10,25,50,100 | 25.4 ± 2.0 |
68 | CYP11A1 + | NPS-D1-000034-G08 | 10 | 100 | 83.5 | * | CPK-M1-014009-F05 | 1,5,10,25,50,100 | 38.0 ± 2.8 |
69 | CYP11A1 + | NPS-D1-000027-E11 | 10 | 100 | 83.0 | ** | CPK-M1-014010-E03 | 1,5,10,25,50,100 | 108.8 ± 2.1 |
70 | CYP11A1 + | NPS-D1-000028-D12 | 10 | 100 | 82.8 | * | CPK-M1-014009-F11 | 1,5,10,25,50,100 | 101.4 ± 2.0 |
71 | CYP11A1 + | NPS-D1-000036-H07 | 10 | 100 | 82.7 | **** | CPK-M1-014010-F09 | 1,5,10,25,50,100 | 61.8 ± 2.5 |
72 | CYP11A1 + | NPS-D1-000031-E04 | 10 | 100 | 82.7 | ** | CPK-M1-014010-C05 | 1,5,10,25,50,100 | 62.0 ± 1.8 |
73 | CYP11A1 + | NPS-D1-000031-E06 | 10 | 100 | 82.6 | **** | CPK-M1-014009-D11 | 1,5,10,25,50,100 | 121.0 ± 1.9 |
74 | CYP11A1 + | NPS-D1-000028-D05 | 10 | 100 | 82.4 | ** | CPK-M1-014009-C11 | 1,5,10,25,50,100 | 111.3 ± 1.9 |
75 | CYP11A1 + | NPS-D1-000035-E05 | 10 | 100 | 82.2 | * | CPK-M1-014010-B04 | 1,5,10,25,50,100 | 83.2 ± 2.1 |
76 | CYP11A1 + | NPS-D1-000029-C08 | 10 | 100 | 82.2 | * | CPK-M1-014009-G03 | 1,5,10,25,50,100 | 44.6 ± 3.7 |
77 | CYP11A1 + | NPS-D1-000036-F03 | 10 | 100 | 82.1 | **** | CPK-M1-014010-C06 | 1,5,10,25,50,100 | 44.5 ± 3.8 |
78 | CYP11A1 + | NPS-D1-000029-G08 | 10 | 100 | 82.0 | ** | CPK-M1-014010-G06 | 1,5,10,25,50,100 | 46.2 ± 2.7 |
79 | CYP11A1 + | NPS-D1-000027-C12 | 10 | 100 | 82.0 | ** | CPK-M1-014009-F09 | 1,5,10,25,50,100 | 70.1 ± 2.8 |
80 | CYP11A1 + | NPS-D1-000043-D06 | 10 | 100 | 81.9 | **** | ─ | ─ | ─ |
81 | CYP11A1 + | NPS-D1-000037-B04 | 10 | 100 | 81.9 | **** | CPK-M1-014010-D08 | 1,5,10,25,50,100 | 27.6 ± 3.4 |
82 | CYP11A1 + | NPS-D1-000036-F06 | 10 | 100 | 81.8 | ** | CPK-M1-014009-F04 | 1,5,10,25,50,100 | 73.7 ± 2.1 |
83 | CYP11A1 + | NPS-D1-000041-D12 | 10 | 100 | 81.7 | ** | CPK-M1-014009-H05 | 1,5,10,25,50,100 | 77.2 ± 2.1 |
84 | CYP11A1 + | NPS-D1-000027-G11 | 10 | 100 | 81.7 | * | CPK-M1-014009-G11 | 1,5,10,25,50,100 | 90.6 ± 1.9 |
85 | CYP11A1 + | NPS-D1-000039-H03 | 10 | 100 | 81.6 | * | CPK-M1-014009-B08 | 1,5,10,25,50,100 | 109.8 ± 1.7 |
86 | CYP11A1 + | NPS-D1-000029-G04 | 10 | 100 | 81.5 | * | CPK-M1-014009-E11 | 1,5,10,25,50,100 | 155.4 ± 1.5 |
87 | CYP11A1 + | NPS-D1-000035-B09 | 10 | 100 | 81.5 | ** | CPK-M1-014009-D06 | 1,5,10,25,50,100 | 40.5 ± 3.6 |
88 | CYP11A1 + | NPS-D1-000029-A07 | 10 | 100 | 81.4 | ** | CPK-M1-014009-B04 | 1,5,10,25,50,100 | 62.0 ± 1.4 |
89 | CYP11A1 + | NPS-D1-000039-D04 | 10 | 100 | 81.2 | ** | CPK-M1-014010-F03 | 1,5,10,25,50,100 | 24.6 ± 1.8 |
90 | CYP11A1 + | NPS-D1-000036-B05 | 10 | 100 | 81.0 | *** | CPK-M1-014010-D04 | 1,5,10,25,50,100 | 88.5 ± 2.0 |
91 | CYP11A1 + | NPS-D1-000030-E09 | 10 | 100 | 80.9 | * | CPK-M1-014010-C03 | 1,5,10,25,50,100 | 93.5 ± 1.7 |
92 | CYP11A1 + | NPS-D1-000036-H06 | 10 | 100 | 80.8 | **** | CPK-M1-014009-G07 | 1,5,10,25,50,100 | 105.9 ± 1.7 |
93 | CYP11A1 + | NPS-D1-000035-H09 | 10 | 100 | 80.8 | * | CPK-M1-014010-B09 | 1,5,10,25,50,100 | 289.5 ± 0.8 |
94 | CYP11A1 + | NPS-D1-000036-H05 | 10 | 100 | 80.7 | **** | CPK-M1-014010-D09 | 1,5,10,25,50,100 | 42.4 ± 3.3 |
95 | CYP11A1 + | NPS-D1-000041-G10 | 10 | 100 | 80.6 | * | CPK-M1-014010-E10 | 1,5,10,25,50,100 | 5.9 ± 2.1 |
96 | CYP11A1 + | NPS-D1-000029-A05 | 10 | 100 | 80.5 | **** | CPK-M1-014009-A07 | 1,5,10,25,50,100 | 26.3 ± 3.1 |
97 | CYP11A1 + | NPS-D1-000035-C10 | 10 | 100 | 80.3 | **** | CPK-M1-014009-H12 | 1,5,10,25,50,100 | 106.1 ± 1.5 |
98 | CYP11A1 + | NPS-D1-000027-B11 | 10 | 100 | 80.2 | * | CPK-M1-014010-D12 | 1,5,10,25,50,100 | 55.7 ± 2.6 |
99 | CYP11A1 + | NPS-D1-000032-B04 | 10 | 100 | 79.9 | ** | CPK-M1-014009-A09 | 1,5,10,25,50,100 | 24.2 ± 1.8 |
100 | CYP11A1 + | NPS-D1-000035-A09 | 10 | 100 | 79.8 | ** | CPK-M1-014010-B05 | 1,5,10,25,50,100 | 54.4 ± 2.1 |
101 | CYP11A1 + | NPS-D1-000036-B06 | 10 | 100 | 79.7 | ** | CPK-M1-014010-G09 | 1,5,10,25,50,100 | 55.0 ± 2.3 |
102 | CYP11A1 + | NPS-D1-000028-H11 | 10 | 100 | 79.7 | * | CPK-M1-014009-B11 | 1,5,10,25,50,100 | 121.5 ± 1.7 |
103 | CYP11A1 + | NPS-D1-000043-H09 | 10 | 100 | 79.7 | * | ─ | ─ | ─ |
104 | CYP11A1 + | NPS-D1-000030-E05 | 10 | 100 | 79.6 | **** | CPK-M1-014009-A05 | 1,5,10,25,50,100 | 175.8 ± 1.2 |
105 | CYP11A1 + | NPS-D1-000029-D08 | 10 | 100 | 79.6 | * | CPK-M1-014010-F04 | 1,5,10,25,50,100 | 115.8 ± 1.8 |
106 | CYP11A1 + | NPS-D1-000043-H03 | 10 | 100 | 79.5 | * | ─ | ─ | ─ |
107 | CYP11A1 + | NPS-D1-000034-E09 | 10 | 100 | 79.5 | ** | CPK-M1-014009-A04 | 1,5,10,25,50,100 | 41.4 ± 2.6 |
108 | CYP11A1 + | NPS-D1-000029-F09 | 10 | 100 | 79.4 | **** | CPK-M1-014009-B12 | 1,5,10,25,50,100 | 112.8 ± 2.0 |
109 | CYP11A1 + | NPS-D1-000035-G03 | 10 | 100 | 79.1 | * | CPK-M1-014010-H11 | 1,5,10,25,50,100 | 69.1 ± 1.5 |
110 | CYP11A1 + | NPS-D1-000041-C12 | 10 | 100 | 79.1 | * | CPK-M1-014009-F08 | 1,5,10,25,50,100 | 124.4 ± 1.5 |
111 | CYP11A1 + | NPS-D1-000033-D07 | 10 | 100 | 79.0 | **** | CPK-M1-014009-E09 | 1,5,10,25,50,100 | 76.8 ± 2.3 |
112 | CYP11A1 + | NPS-D1-000042-A03 | 10 | 100 | 78.9 | ** | CPK-M1-014010-F07 | 1,5,10,25,50,100 | 97.6 ± 2.0 |
113 | CYP11A1 + | NPS-D1-000040-B08 | 10 | 100 | 78.9 | *** | CPK-M1-014010-D10 | 1,5,10,25,50,100 | 85.5 ± 3.3 |
114 | CYP11A1 + | NPS-D1-000029-E07 | 10 | 100 | 78.9 | ** | CPK-M1-014009-G04 | 1,5,10,25,50,100 | 62.9 ± 3.8 |
115 | CYP11A1 + | NPS-D1-000040-G11 | 10 | 100 | 78.8 | *** | CPK-M1-014010-E04 | 1,5,10,25,50,100 | 65.0 ± 2.4 |
116 | CYP11A1 + | NPS-D1-000036-B09 | 10 | 100 | 78.5 | **** | CPK-M1-014010-A12 | 1,5,10,25,50,100 | 143.9 ± 1.5 |
117 | CYP11A1 + | NPS-D1-000030-B09 | 10 | 100 | 78.5 | * | CPK-M1-014009-E07 | 1,5,10,25,50,100 | 19.8 ± 2.0 |
118 | CYP11A1 + | NPS-D1-000031-E07 | 10 | 100 | 78.5 | **** | CPK-M1-014010-B03 | 1,5,10,25,50,100 | 120.2 ± 1.4 |
119 | CYP11A1 + | NPS-D1-000030-F12 | 10 | 100 | 78.4 | **** | CPK-M1-014010-D06 | 1,5,10,25,50,100 | 200.2 ± 0.9 |
120 | CYP11A1 + | NPS-D1-000027-E06 | 10 | 100 | 78.3 | **** | CPK-M1-014010-B12 | 1,5,10,25,50,100 | 58.6 ± 3.5 |
121 | CYP11A1 + | NPS-D1-000028-D04 | 10 | 100 | 78.1 | * | CPK-M1-014009-D10 | 1,5,10,25,50,100 | 121.8 ± 1.9 |
122 | CYP11A1 + | NPS-D1-000028-C04 | 10 | 100 | 78.0 | **** | CPK-M1-014010-C11 | 1,5,10,25,50,100 | 78.9 ± 1.4 |
123 | CYP11A1 + | NPS-D1-000027-D10 | 10 | 100 | 77.9 | ** | CPK-M1-014010-D11 | 1,5,10,25,50,100 | 35.6 ± 3.3 |
124 | CYP11A1 + | NPS-D1-000036-H11 | 10 | 100 | 77.8 | *** | CPK-M1-014009-A08 | 1,5,10,25,50,100 | 108.1 ± 2.0 |
125 | CYP11A1 + | NPS-D1-000028-B04 | 10 | 100 | 77.7 | **** | CPK-M1-014010-G10 | 1,5,10,25,50,100 | 193.4 ± 3.0 |
126 | CYP11A1 + | NPS-D1-000028-B12 | 10 | 100 | 77.6 | **** | CPK-M1-014009-E06 | 1,5,10,25,50,100 | 51.4 ± 2.9 |
127 | CYP11A1 + | NPS-D1-000028-H03 | 10 | 100 | 77.6 | *** | CPK-M1-014010-A08 | 1,5,10,25,50,100 | 52.2 ± 1.7 |
128 | CYP11A1 + | NPS-D1-000030-C11 | 10 | 100 | 77.5 | ** | CPK-M1-014009-H11 | 1,5,10,25,50,100 | 101.7 ± 1.4 |
129 | CYP11A1 + | NPS-D1-000041-G08 | 10 | 100 | 77.4 | ** | CPK-M1-014010-H08 | 1,5,10,25,50,100 | 13.6 ± 2.1 |
130 | CYP11A1 + | NPS-D1-000029-E05 | 10 | 100 | 77.3 | **** | CPK-M1-014010-B06 | 1,5,10,25,50,100 | 145.9 ± 1.6 |
131 | CYP11A1 + | NPS-D1-000028-F05 | 10 | 100 | 77.2 | * | CPK-M1-014009-F10 | 1,5,10,25,50,100 | 69.0 ± 1.5 |
132 | CYP11A1 + | NPS-D1-000030-F09 | 10 | 100 | 77.2 | ** | CPK-M1-014009-H08 | 1,5,10,25,50,100 | 69.2 ± 1.5 |
133 | CYP11A1 + | NPS-D1-000027-D12 | 10 | 100 | 77.0 | * | CPK-M1-014009-G08 | 1,5,10,25,50,100 | 86.0 ± 2.2 |
134 | CYP11A1 + | NPS-D1-000028-G05 | 10 | 100 | 76.9 | * | CPK-M1-014010-A05 | 1,5,10,25,50,100 | 54.7 ± 2.5 |
135 | CYP11A1 + | NPS-D1-000035-F09 | 10 | 100 | 76.8 | **** | CPK-M1-014010-B10 | 1,5,10,25,50,100 | 246.3 ± 3.8 |
136 | CYP11A1 + | NPS-D1-000034-D07 | 10 | 100 | 76.7 | ** | CPK-M1-014010-B08 | 1,5,10,25,50,100 | 37.5 ± 2.8 |
137 | CYP11A1 + | NPS-D1-000036-E08 | 10 | 100 | 76.7 | * | CPK-M1-014009-G05 | 1,5,10,25,50,100 | 166.6 ± 1.4 |
138 | CYP11A1 + | NPS-D1-000039-B07 | 10 | 100 | 76.5 | ** | CPK-M1-014010-D05 | 1,5,10,25,50,100 | 90.8 ± 0.8 |
139 | CYP11A1 + | NPS-D1-000028-E10 | 10 | 100 | 76.5 | **** | CPK-M1-014010-H10 | 1,5,10,25,50,100 | 117.4 ± 1.5 |
140 | CYP11A1 + | NPS-D1-000043-F08 | 10 | 100 | 76.5 | **** | ─ | ─ | ─ |
141 | CYP11A1 + | NPS-D1-000038-D11 | 10 | 100 | 76.5 | ** | CPK-M1-014009-H04 | 1,5,10,25,50,100 | 51.1 ± 3.8 |
142 | CYP11A1 + | NPS-D1-000028-H08 | 10 | 100 | 76.4 | * | CPK-M1-014009-B05 | 1,5,10,25,50,100 | 137.2 ± 1.6 |
143 | CYP11A1 + | NPS-D1-000041-G07 | 10 | 100 | 76.2 | **** | CPK-M1-014010-C07 | 1,5,10,25,50,100 | 67.2 ± 1.8 |
144 | CYP11A1 + | NPS-D1-000036-H03 | 10 | 100 | 76.2 | ** | CPK-M1-014010-F12 | 1,5,10,25,50,100 | 64.4 ± 1.6 |
145 | CYP11A1 + | NPS-D1-000032-C03 | 10 | 100 | 76.2 | ** | CPK-M1-014009-B10 | 1,5,10,25,50,100 | 95.1 ± 1.5 |
146 | CYP11A1 + | NPS-D1-000035-F10 | 10 | 100 | 76.2 | ** | CPK-M1-014009-E04 | 1,5,10,25,50,100 | 70.2 ± 1.9 |
147 | CYP11A1 + | NPS-D1-000029-B08 | 10 | 100 | 76.2 | **** | CPK-M1-014009-H07 | 1,5,10,25,50,100 | 39.9 ± 2.6 |
148 | CYP11A1 + | NPS-D1-000040-C11 | 10 | 100 | 76.0 | * | CPK-M1-014010-E05 | 1,5,10,25,50,100 | 84.2 ± 1.5 |
149 | CYP11A1 + | NPS-D1-000036-F07 | 10 | 100 | 75.9 | *** | CPK-M1-014010-A04 | 1,5,10,25,50,100 | 14.5 ± 1.0 |
150 | CYP11A1 + | NPS-D1-000035-D11 | 10 | 100 | 75.9 | * | CPK-M1-014010-C09 | 1,5,10,25,50,100 | 192.3 ± 1.1 |
151 | CYP11A1 + | NPS-D1-000036-B12 | 10 | 100 | 75.8 | * | CPK-M1-014009-A11 | 1,5,10,25,50,100 | 89.2 ± 2.3 |
152 | CYP11A1 + | NPS-D1-000035-C12 | 10 | 100 | 75.6 | **** | CPK-M1-014010-D03 | 1,5,10,25,50,100 | 57.5 ± 2.0 |
153 | CYP11A1 + | NPS-D1-000041-E11 | 10 | 100 | 75.6 | **** | CPK-M1-014009-E08 | 1,5,10,25,50,100 | 73.4 ± 2.4 |
154 | CYP11A1 + | NPS-D1-000031-F04 | 10 | 100 | 75.6 | * | CPK-M1-014010-H05 | 1,5,10,25,50,100 | 96.2 ± 1.7 |
155 | CYP11A1 + | NPS-D1-000040-C08 | 10 | 100 | 75.6 | ** | CPK-M1-014010-A06 | 1,5,10,25,50,100 | 76.4 ± 2.5 |
156 | CYP11A1 + | NPS-D1-000036-C05 | 10 | 100 | 75.4 | ** | CPK-M1-014009-A03 | 1,5,10,25,50,100 | 46.4 ± 2.0 |
157 | CYP11A1 + | NPS-D1-000034-E10 | 10 | 100 | 75.3 | **** | CPK-M1-014009-A12 | 1,5,10,25,50,100 | 28.7 ± 3.6 |
158 | CYP11A1 + | NPS-D1-000036-H04 | 10 | 100 | 75.3 | * | CPK-M1-014010-F05 | 1,5,10,25,50,100 | 22.7 ± 2.4 |
159 | CYP11A1 + | NPS-D1-000028-B10 | 10 | 100 | 75.3 | * | CPK-M1-014010-G08 | 1,5,10,25,50,100 | 59.3 ± 1.5 |
160 | CYP11A1 + | NPS-D1-000044-F04 | 10 | 100 | 75.2 | **** | ─ | ─ | ─ |
161 | CYP11A1 + | NPS-D1-000040-E10 | 10 | 100 | 75.2 | ** | CPK-M1-014010-B07 | 1,5,10,25,50,100 | 83.2 ± 2.1 |
162 | CYP11A1 + | NPS-D1-000031-B04 | 10 | 100 | 75.2 | **** | CPK-M1-014009-D07 | 1,5,10,25,50,100 | 81.9 ± 1.8 |
163 | CYP11A1 + | NPS-D1-000028-F04 | 10 | 100 | 75.1 | * | CPK-M1-014010-C12 | 1,5,10,25,50,100 | 193.3 ± 0.9 |
164 | CYP11A1 + | NPS-D1-000029-B05 | 10 | 100 | 75.1 | **** | CPK-M1-014009-E03 | 1,5,10,25,50,100 | 39.5 ± 2.5 |
165 | CYP11A1 + | NPS-D1-000028-F03 | 10 | 100 | 75.0 | ** | CPK-M1-014009-F07 | 1,5,10,25,50,100 | 77.3 ± 2.0 |
166 | CYP11A1 + | NPS-D1-000027-B10 | 10 | 100 | 75.0 | ** | CPK-M1-014010-G12 | 1,5,10,25,50,100 | 70.8 ± 1.6 |
167 | CYP11A1 + | NPS-D1-000038-A12 | 10 | 100 | 75.0 | **** | CPK-M1-014009-B03 | 1,5,10,25,50,100 | 48.4 ± 1.9 |