Fig. 9

Schematic diagram of the MSI2-MAPK-HSPB1 axis in CRC ferroptosis. MSI2 deficiency suppresses the growth and survival of CRC cells and promote ferroptosis by reducing interaction with p-ERK and inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis