Fig. 9

CLSPN associated with cell cycle signal. A Functional enrichment analysis of CLSPN through GSEA. B The correlation between CLSPN expression and CCNA2, CCNB1, CCNB2, CCNE2, CDK1, CDK2, CDK4 and CDK6 in the GEPIA2.0 database. C RT-qPCR validated the mRNA expression of CCNA2, CCNB1, CCNB2, CCNE2, CDK1, CDK2, CDK4 and CDK6 after knockdown CLSPN. D Knockdown CLSPN significantly inhibited the protein expression of CCNA2, CCNB1, CDK1 and CDK2 in A549 and PC9 cells. *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance