Fig. 5From: Macrophage-Derived MMP-9 and MMP-2 are Closely Related to the Rupture of the Fibrous Capsule of Hepatocellular Carcinoma Leading to Tumor InvasionMMP-9 and MMP-2 are derived from macrophages causing FC rupture. A Immunohistochemical staining for MMP-9 in the ruptured FC (n = 3), and a significant number of the macrophages in the area of the ruptured FC. B Immunohistochemical staining for MMP-9 in the ruptured FC (n = 3), and a significant number of MMP-9 was aggregated in the ruptured area of the FC. C Immunohistochemical staining for MMP-2 in the ruptured FC (n = 3), and a significant number of MMP-2 was concentrated in the ruptured area of the FC. D Immunofluorescence staining of CD163 and MMP-9 (n = 3), with co-localization of CD163 and MMP-9. E Immunofluorescence staining of CD163 and MMP-2 (n = 3), with co-localization of CD163 and MMP-2. HCC tumor tissues are indicated by T and the paracancerous liver tissues are indicated by N. The red line adjacent to the cancerous tissue is FC; the red arrow indicates the FC ruptured area whose direction is the direction of tumor cells breaking through the ruptured area of FC to invade the paracancerous liver tissue. The blue and white arrows are the points where the three are co-locatedBack to article page