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Table 3 Univariate and multivariate analyses of the recurrence-free survival in 110 HCC cases

From: Circadian gene CSNK1D promoted the progression of hepatocellular carcinoma by activating Wnt/β-catenin pathway via stabilizing Dishevelled Segment Polarity Protein 3

Parameters

Univariate analysis

Multivariate analysis

HR

95%CI

P

HR

95%CI

P

CSNK1D expression

 High vs. low

2.133

1.344–3.386

0.001

1.758

1.039–2.972

0.035

Sex

 Male vs. female

0.958

0.516–1.778

0.892

   

Age

  < 50 vs. ≥ 50

0.678

0.425–1.080

0.102

   

AFP

  < 400 vs. ≥ 400

1.736

1.099–2.740

0.018

1.665

1.053–2.634

0.069

Tumor size

  < 5 vs. ≥ 5

2.297

1.386–3.809

0.001

1.749

1.036–2.951

0.097

Tumor differentiation

 Well vs. Moderate & Poor

1.954

1.168–3.268

0.011

1.885

1.125–3.157

0.003

Microvascular invasion

 Yes vs. No

4.696

2.681–8.226

 < 0.001

4.016

2.210–7.299

0.061

TNM stage

 I-II vs. III-IV

2.522

1.501–4.238

 < 0.001

1.887

1.089–3.271

0.024

Tumor number

 Single vs. Multiple

2.382

1.461–3.884

 < 0.001

2.530

1.507–4.248

0.051

HBV-DNA

  ≤ 1000 vs. > 1000

1.130

0.718–1.778

0.599

   

Liver cirrhosis

 Yes vs. No

1.130

0.714–1.789

0.602

   

Metastasis

 Yes vs. No

1.154

0.421–3.168

0.781

   
  1. AFP alpha-fetoprotein, TNM tumor-node-metastasis
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