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Table 2 Univariate and multivariate analyses of the overall survival in 110 HCC cases

From: Circadian gene CSNK1D promoted the progression of hepatocellular carcinoma by activating Wnt/β-catenin pathway via stabilizing Dishevelled Segment Polarity Protein 3

Parameters

Univariate analysis

Multivariate analysis

HR

95%CI

P

HR

95%CI

P

CSNK1D expression

 High vs. low

2.016

1.268–3.204

0.003

1.937

1.217–3.084

0.005

Sex

 Male vs. female

0.849

0.456–1.581

0.606

   

Age

  < 50 vs. ≥ 50

0.793

0.497–1.266

0.331

   

AFP

  < 400 vs. ≥ 400

1.735

1.095–2.750

0.019

1.642

1.034–2.606

0.066

Tumor size

  < 5 vs. ≥ 5

2.477

1.480–4.147

0.001

1.745

1.029–2.959

0.059

Tumor differentiation

 Well vs. Moderate & Poor

2.352

1.386–3.990

0.002

1.773

0.969–3.244

 < 0.001

Microvascular invasion

 Yes vs. No

3.224

1.905–5.456

 < 0.001

2.388

1.392–4.098

0.082

TNM stage

 I-II vs. III-IV

2.594

1.531–4.394

 < 0.001

1.855

1.040–3.309

0.036

Tumor number

 Single vs. Multiple

2.706

1.652–4.432

 < 0.001

3.072

1.826–5.166

0.052

HBV-DNA

  < 1000 vs. ≥ 1000

1.325

0.838–2.097

0.229

   

Liver cirrhosis

 Yes vs. No

1.083

0.682–1.718

0.736

   

Metastasis

 Yes vs. No

1.434

0.521–3.949

0.485

   
  1. AFP alpha-fetoprotein, TNM tumor-node-metastasis
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