Circadian gene CSNK1D promoted the progression of hepatocellular carcinoma by activating Wnt/β-catenin pathway via stabilizing Dishevelled Segment Polarity Protein 3

Table 1 Correlation of CSNK1D expression with clinical features in 110 HCC patients

Parameters	n	CSNK1D expression		P
Parameters		Low	High
Sex				0.065
Male	93	43	50
Female	17	12	5
Age				0.335
< 50	63	29	34
≥ 50	47	26	21
AFP(ng/ml)				0.175
< 400	65	36	29
≥ 400	45	19	26
Tumor size				0.01
< 5 cm	41	27	14
≥ 5 cm	69	28	41
Differentiation				< 0.001
Well	35	32	3
Moderate & Poor	75	23	52
Microvascular Invasion				0.021
Yes	24	7	17
No	86	48	38
TNM stage				< 0.001
I-II	39	30	9
III-IV	71	25	46
Tumor number				0.825
Single	83	41	42
Multiple	27	14	13
HBV-DNA				0.849
< 1000	55	28	27
≥ 1000	55	27	28
Liver cirrhosis				0.563
Yes	63	33	30
No	47	22	25
Metastasis				0.012
Yes	6	0	6
No	104	55	49
Recurrence				0.008
Yes	52	19	33
No	58	36	22

ISSN: 1480-9222